Regulation of the activity of histamine-N-methyltransferase from guinea pig skin by biogenic amines.

@article{Tachibana1986RegulationOT,
  title={Regulation of the activity of histamine-N-methyltransferase from guinea pig skin by biogenic amines.},
  author={Takao Tachibana and Shinkichi Taniguchi and Michihiro Fujiwara and Sadao Imamura},
  journal={Experimental and molecular pathology},
  year={1986},
  volume={45 3},
  pages={257-69}
}
Histamine-N-methyltransferase, a major histamine-degrading enzyme in the skin, was purified from guinea pig skin about 150-fold. The enzymological characteristics including pH optimum, Km values for substrates, and molecular weight were almost consistent with those reported in the brain. Regulatory mechanism of the enzyme activity by biogenic amines was investigated using the purified specimen. Serotonin, tryptamine, and 5-methoxytryptamine intensely inhibited the activity while tryptophan… CONTINUE READING