Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation.

@article{Zhang1998RegulationOT,
  title={Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation.},
  author={Feng Zhang and Ding Zhi Wang and Mark R Boothby and Laroy Penix and Richard A Flavell and Thomas M. Aune},
  journal={Journal of immunology},
  year={1998},
  volume={161 11},
  pages={
          6105-12
        }
}
Before they can deliver their effector functions, CD4+ Th cells must differentiate into Th1 or Th2 subsets. We have prepared reporter transgenic mice that express the luciferase gene under the control of proximal (prox.IFN-gamma) and distal (dist.IFN-gamma) regulatory elements from the IFN-gamma promoter to permit investigation of mechanisms that regulate IFN-gamma gene transcription during Th cell differentiation. Precursor Th cells (pTh) contain high levels of cAMP response element binding… CONTINUE READING

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