Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function.

@article{VouretCraviari1998RegulationOT,
  title={Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function.},
  author={Val{\'e}rie Vouret-Craviari and Patrice Boquet and Jacques M. Pouyssegur and Ellen Van Obberghen-Schilling},
  journal={Molecular biology of the cell},
  year={1998},
  volume={9 9},
  pages={2639-53}
}
Endothelial barrier function is regulated at the cellular level by cytoskeletal-dependent anchoring and retracting forces. In the present study we have examined the signal transduction pathways underlying agonist-stimulated reorganization of the actin cytoskeleton in human umbilical vein endothelial cells. Receptor activation by thrombin, or the thrombin receptor (proteinase-activated receptor 1) agonist peptide, leads to an early increase in stress fiber formation followed by cortical actin… CONTINUE READING
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