Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes

@article{Guo2002RegulationOT,
  title={Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes},
  author={Jian Guo and Abbas Hawwari and Hong Kun Li and Zuoming Sun and Sanjeev K. Mahanta and Dan R. Littman and Michael S Krangel and You-Wen He},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={469-476}
}
T cell receptor (TCR) α alleles undergo primary and secondary rearrangement in double-positive (DP) thymocytes. By analyzing TCRα rearrangement in orphan nuclear receptor RORγ-deficient mice, in which the DP lifespan is shorter, and in Bcl-xL–transgenic mice, in which the DP lifespan is extended, we show that the progression of secondary Vα to Jα rearrangements is controlled by DP thymocyte survival. In addition, because Bcl-xL induces a bias towards 3′ Jα usage in peripheral T cells, we… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

P.T early α (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence

L. Mauvieux, I. Villey, J. de Villartay
  • Eur. J. Immunol
  • 2001

The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development

Y. W. He
  • Immunol . Res .
  • 2001

The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo

N Yannoutsos
  • J. Exp. Med. 194,
  • 2001

role of secondary rearrangement in thymic selection

C. Huang, Kanagawa, O. Ordered, coordinated rearrangement of the TCRα locus
  • J. Immunol. 166, 2597–2601
  • 2001