Regulation of the Streptomyces coelicolor Calcium-Dependent Antibiotic by absA, Encoding a Cluster-Linked Two-Component System

@article{Ryding2002RegulationOT,
  title={Regulation of the Streptomyces coelicolor Calcium-Dependent Antibiotic by absA, Encoding a Cluster-Linked Two-Component System},
  author={N J Ryding and Todd B. Anderson and Wendy C. Champness},
  journal={Journal of Bacteriology},
  year={2002},
  volume={184},
  pages={794 - 805}
}
ABSTRACT The Streptomyces coelicolor absA two-component system was initially identified through analysis of mutations in the sensor kinase absA1 that caused inhibition of all four antibiotics synthesized by this strain. Previous genetic analysis had suggested that the phosphorylated form of AbsA2 acted as a negative regulator of antibiotic biosynthesis in S. coelicolor (T. B. Anderson, P. Brian, and W. C. Champness, Mol. Microbiol. 39:553–566, 2001). Genomic sequence data subsequently provided… Expand
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  • Medicine
  • Current microbiology
  • 2021
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The role of MacRS was further extended to include control of the production of the red-pigmented antibiotic undecylprodigiosin and the calcium-dependent antibiotic and its potential application in strain engineering, and control of other important cellular activities. Expand
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