Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress.

@article{Proft2001RegulationOT,
  title={Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress.},
  author={Markus Proft and Amparo Pascual-Ahuir and Eul{\`a}lia de Nadal and Joaqu{\'i}n Ari{\~n}o and Ram{\'o}n Serrano and Francesc Posas},
  journal={The EMBO journal},
  year={2001},
  volume={20 5},
  pages={1123-33}
}
Exposure of yeast to increases in extracellular osmolarity activates the Hog1 mitogen-activated protein kinase (MAPK), which is essential for the induction of gene expression required for cell survival upon osmotic stress. Several genes are regulated in response to osmotic stress by Sko1, a transcriptional repressor of the ATF/CREB family. We show by in vivo coprecipitation and phosphorylation studies that Sko1 and Hog1 interact and that Sko1 is phosphorylated upon osmotic stress in a Hog1… CONTINUE READING
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