Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis.

@article{Park2008RegulationOT,
  title={Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis.},
  author={Sang Tae Park and Choong-Min Kang and Robert N Husson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 35},
  pages={
          13105-10
        }
}
SigH is a key regulator of an extensive transcriptional network that responds to oxidative, nitrosative, and heat stresses in Mycobacterium tuberculosis, and this sigma factor is required for virulence in animal models of infection. SigH is negatively regulated by RshA, its cognate anti-sigma factor, which functions as a stress sensor and redox switch. While RshA provides a direct mechanism for sensing stress and activating transcription, bacteria use several types of signal transduction… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS, ESTIMATED 63% COVERAGE

60 Citations

0510'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 60 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Mycobacteirum tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog

  • AE Greenstein
  • PLoS Pathog 3:e49
  • 2007
1 Excerpt

The Role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolor

  • W Li
  • J Mol Biol
  • 2003

Similar Papers

Loading similar papers…