Regulation of the Shiga-like toxin II operon in Escherichia coli.

  title={Regulation of the Shiga-like toxin II operon in Escherichia coli.},
  author={Inge Muehldorfer and Joerg Hacker and Gerald T Keusch and David W. K. Acheson and Helmut Tsch{\"a}pe and Anne V. Kane and A. William Ritter and Tobias A Olschl{\"a}ger and Arthur Donohue-Rolfe},
  journal={Infection and immunity},
  volume={64 2},
Investigations of the regulation of the bacteriophage-encoded Shiga-like toxin II (SLT-II) in Escherichia coli demonstrated that bacteriophages exhibit a regulatory impact on toxin production by two mechanisms. Firstly, replication of the toxin-converting bacteriophages brings about an increase in toxin production due to concomitant multiplication of toxin gene copies. Secondly, an influence of a phage-encoded regulatory molecule was demonstrated by using low-copy-number plasmid pADR-28… CONTINUE READING