Regulation of the Serotonergic System by Kainate in the Avian Retina

  title={Regulation of the Serotonergic System by Kainate in the Avian Retina},
  author={Adelaide C F Passos and Anderson Manoel Herculano and Karen Renata Matos Oliveira and Silene Maria A de Lima and Fernando Allan F Rocha and H{\'e}rcules Rezende Freitas and Luzia da Silva Sampaio and Danniel Pereira Figueiredo and Karin da Costa Calaza and Ricardo Augusto de Melo Reis and Jos{\'e} Luiz Martins do Nascimento},
  journal={Cellular and Molecular Neurobiology},
Serotonin (5-HT) has been recognized as a neurotransmitter in the vertebrate retina, restricted mainly to amacrine and bipolar cells. It is involved with synaptic processing and possibly as a mitogenic factor. We confirm that chick retina amacrine and bipolar cells are, respectively, heavily and faintly immunolabeled for 5-HT. Amacrine serotonergic cells also co-express tyrosine hydroxylase (TH), a marker of dopaminergic cells in the retina. Previous reports demonstrated that serotonin… 
1 Citations

Cell Calcium Imaging as a Reliable Method to Study Neuron–Glial Circuits

Complex dynamic cellular networks have been studied in physiological and pathological processes under the light of single-cell calcium imaging (SCCI), a method that correlates functional data based



Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: implications in physiological functions and in pathology.

  • L. Ciranna
  • Biology, Psychology
    Current neuropharmacology
  • 2006
This review will focus on the modulatory action of 5-HT on the effects of glutamate and gamma-amino-butyric acid, which are the principal neurotransmitters mediating respectively excitatory and inhibitory signals in the CNS.

Immunocytochemical identification of serotonin-synthesizing neurons in the vertebrate retina: a comparative study.

It is suggested that serotonin may not be a primary neurotransmitter in the serotonin-accumulating bipolar and amacrine cells of the non-mammalian retina, while some serotonin-immunoreactive amacine and bipolar cells possibly only accumulate serotonin.

The effect of kainate on protein kinase C, GABA, and the uptake of serotonin in the rabbit retina in vivo

The electrophoresis/blotting experiments of tissues exposed for 5 hours (but not one hour to kainate) established clearly that α, δ, and ɛPKC are translocated from cytosolic and membrane compartments.

Serotonin‐Containing Neurones in Vertebrate Retinas

Results suggest that the neuronal elements that contain endogenous serotonin also have the capacity to accumulate exogenous amine and are consistent with the opinion that serotonin has a neuronal function in retinas of a variety of vertebrates.

Serotonin-like immunoreactivity in the retina of the clawed frogXenopus laevis

The uneven distribution of serotonin-containing elements in the Xenopus retina with its peak falling onto the retinal area which generates binocular vision, suggests its involvement in binocular perception.

Kainate receptors and synaptic transmission

Serotonin receptor 2C regulates neurite growth and is necessary for normal retinal processing of visual information

The findings demonstrate that 5HTR2C regulates neurite growth and RGC activity and is necessary for normal amplitude of RGC response to physiologic stimuli, and raise the hypothesis that these functions are modulated by a subset of 5HT+/ChAT‐/TH+ amacrine cells as part of retinal serotonergic circuitry.

Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina

It is demonstrated that exogenous serotonin transiently accumulates in a distinct type of bipolar neuron, and it is concluded that the serotonin‐accumulating bipolar neurons perform glial functions in the retina by actively transporting and degrading serotonin that is synthesized in neighboring amacrine cells.

GABA release induced by aspartate-mediated activation of NMDA receptors is modulated by dopamine in a selective subpopulation of amacrine cells

It is concluded that, under experimental conditions, both NMDA and aspartate induce the release of GABA exclusively from amacrine cells, and that the release is modulated by dopamine.