Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage

@article{Oravecz1997RegulationOT,
  title={Regulation of the Receptor Specificity and Function of the  Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV  (CD26)-mediated Cleavage },
  author={Tamas Oravecz and Marina Pall and Gregory Roderiquez and Mark D Gorrell and Mary D Ditto and Nga Y. Nguyen and Robert A Boykins and Edward Unsworth and Michael A. Norcross},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1865 - 1872}
}
CD26 is a leukocyte activation marker that possesses dipeptidyl peptidase IV activity but whose natural substrates and immunological functions have not been clearly defined. Several chemo-kines, including RANTES (regulated on activation, normal T cell expressed and secreted), have now been shown to be substrates for recombinant soluble human CD26. The truncated RANTES(3-68) lacked the ability of native RANTES(1-68) to increase the cytosolic calcium concentration in human monocytes, but still… CONTINUE READING
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