Regulation of the Probability of Mouse Odorant Receptor Gene Choice

@article{Khan2011RegulationOT,
  title={Regulation of the Probability of Mouse Odorant Receptor Gene Choice},
  author={Mona Khan and Evelien Vaes and Peter Mombaerts},
  journal={Cell},
  year={2011},
  volume={147},
  pages={907-921}
}
Each olfactory sensory neuron (OSN) in mouse chooses one of 1,200 odorant receptor (OR) genes for expression. OR genes are chosen for expression by greatly varying numbers of OSNs. The mechanisms that regulate the probability of OR gene choice remain unclear. Here, we have applied the NanoString platform of fluorescent barcodes and digital readout to measure RNA levels of 577 OR genes in a single reaction, with probes designed against coding sequences. In an inbred mouse strain with a targeted… CONTINUE READING