Regulation of the Na+/H+ antiporter: evidence for a membrane shuttling mechanism.

  title={Regulation of the Na+/H+ antiporter: evidence for a membrane shuttling mechanism.},
  author={Rene Dr Bloch and Demetrios Zikos and K A Fisher and Ernest J. Sukowski and Edward J. Cragoe and Darryl R. Peterson},
  journal={Contributions to nephrology},
4 Citations
Carbon dioxide affects rat colonic Na+ absorption by modulating vesicular traffic.
CO2 affects Na+ absorption in rat distal colon epithelium in part by modulating the movement of NHE3-containing vesicles to and from the apical membrane.
Active (9.6 S) and Inactive (21 S) Oligomers of NHE3 in Microdomains of the Renal Brush Border*
The data demonstrate that renal brush border NHE3 exists in two oligomeric states: a 9.6 S active form present in microvilli and a 21 S, megalin-associated, inactive form in the intermicrovillar microdomain of the apical plasma membrane.
Increased proximal tubule NHE‐3 and H+‐ATPase activities in spontaneously hypertensive rats
Proximal tubule cells of 5-week-old SHR have higher NHE-3 and H+-ATPase activities compared with age-matched DRY rats, which are likely to contribute to development of high blood pressure in young SHR.
The Epithelial Na+/H+ Exchanger, NHE3, Is Internalized through a Clathrin-mediated Pathway*
Results indicate that endocytosis of NHE3 occurs primarily via clathrin-coated pits and vesicles and that normal intracellular trafficking of N HE3 involves an ε-COP-dependent step.