Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate.

@article{Majewska1990RegulationOT,
  title={Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate.},
  author={Maria Dorota Majewska and James A. Bell and Edythe D. London},
  journal={Brain research},
  year={1990},
  volume={537 1-2},
  pages={328-32}
}
Redox phenomena seem to modulate activity of the N-methyl-D-aspartate receptor. Some reductants (ascorbate, hydroquinone) inhibit, while others (dithiothreitol, mercaptoethanol, penicillamine) potentiate NMDA receptor function. Ascorbate inhibits binding of [3H]glutamate and [3H]thienylcycohexylpiperidine to the NMDA receptor complex, and impedes NMDA-gated currents in isolated neurons; dithiothreitol-like reductants enhance NMDA-induced currents. The ability of reductants to alter function of… CONTINUE READING
35 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…