Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.

@article{Tanaka2003RegulationOT,
  title={Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.},
  author={Tomoaki Tanaka and Hidenori Kawashima and Edward T. H. Yeh and Tetsu Kamitani},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={
          32905-13
        }
}
NEDD8 is a ubiquitin-like protein that controls vital biological events through its conjugation to target proteins. We previously identified a negative regulator of the NEDD8 conjugation system, NUB1, which works by recruiting NEDD8 and its conjugates to the proteasome for degradation. Recently, we found its splicing variant, NUB1L. It possesses an insertion of 14 amino acids that codes for a UBA domain. Structural study revealed that NUB1 has a NEDD8-binding site at the C terminus, whereas… CONTINUE READING

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