Regulation of the NADPH-oxidase complex of phagocytic leukocytes. Recent insights from structural biology, molecular genetics, and microscopy

@article{Robinson2004RegulationOT,
  title={Regulation of the NADPH-oxidase complex of phagocytic leukocytes. Recent insights from structural biology, molecular genetics, and microscopy},
  author={J. Michael Robinson and Taisuke Ohira and John A. Badwey},
  journal={Histochemistry and Cell Biology},
  year={2004},
  volume={122},
  pages={293-304}
}
The NADPH-oxidase complex is a multisubunit enzyme complex that catalyzes the formation of superoxide (O2−) by phagocytic leukocytes. This paper reviews some of the major advances in understanding the assembly and regulation of this enzyme system that have occurred during the past decade. For example, novel domains/motifs have been identified in p47-phox (PX and super SH3 domains) and p67-phox (tetratricopeptide repeat motifs). X-ray crystallography and NMR spectroscopy have provided detailed… CONTINUE READING