Regulation of the Ifng locus in the context of T-lineage specification and plasticity.

@article{Balasubramani2010RegulationOT,
  title={Regulation of the Ifng locus in the context of T-lineage specification and plasticity.},
  author={Anand Balasubramani and Ryuta Mukasa and Robin D Hatton and Casey T Weaver},
  journal={Immunological reviews},
  year={2010},
  volume={238 1},
  pages={216-32}
}
Study of the development of distinct CD4(+) T-cell subsets from naive precursors continues to provide excellent opportunities for dissection of mechanisms that control lineage-specific gene expression or repression. Whereas it had been thought that the induction of transcription networks that control T-lineage commitment were highly stable, reinforced by epigenetic processes that confer heritability of functional phenotypes by the progeny of mature T cells, recent findings support a more… CONTINUE READING