Regulation of the Hsp104 Middle Domain Activity Is Critical for Yeast Prion Propagation

@inproceedings{Dulle2014RegulationOT,
  title={Regulation of the Hsp104 Middle Domain Activity Is Critical for Yeast Prion Propagation},
  author={Jennifer E. Dulle and Kevin C Stein and Heather L True},
  booktitle={PloS one},
  year={2014}
}
Molecular chaperones play a significant role in preventing protein misfolding and aggregation. Indeed, some protein conformational disorders have been linked to changes in the chaperone network. Curiously, in yeast, chaperones also play a role in promoting prion maintenance and propagation. While many amyloidogenic proteins are associated with disease in mammals, yeast prion proteins, and their ability to undergo conformational conversion into a prion state, are proposed to play a functional… CONTINUE READING
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