Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

@article{Jiang1998RegulationOT,
  title={Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb},
  author={Jin Jiang and Gary Struhl},
  journal={Nature},
  year={1998},
  volume={391},
  pages={493-496}
}
Members of the Hedgehog (Hh) and Wnt/Wingless (Wg) families of secreted proteins control many aspects of growth and patterning during animal development,. Hh signal transduction leads to increased stability of a transcription factor, Cubitus interruptus (Ci),, whereas Wg signal transduction causes increased stability of Armadillo (Arm/β-catenin), a possible co-factor for thetranscriptional regulator Lef1/TCF. Here we describe a new gene, slimb (for supernumerary limbs), which negatively… CONTINUE READING
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