Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.

@article{Oner2013RegulationOT,
  title={Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.},
  author={Sukru Sadik Oner and Ellen M. Maher and Meital Gabay and Gregory G Tall and Joe B Blumer and Stephen M Lanier},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 5},
  pages={
          3003-15
        }
}
Group II activators of G-protein signaling (AGS) serve as binding partners for Gα(i/o/t) via one or more G-protein regulatory (GPR) motifs. GPR-Gα signaling modules may be differentially regulated by cell surface receptors or by different nonreceptor guanine nucleotide exchange factors. We determined the effect of the nonreceptor guanine nucleotide exchange factors AGS1, GIV/Girdin, and Ric-8A on the interaction of two distinct GPR proteins, AGS3 and AGS4, with Gα(il) in the intact cell by… CONTINUE READING

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