Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose

@inproceedings{Kos2009RegulationOT,
  title={Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose},
  author={Katrina Kos and Steve G Wong and Bee Kang Tan and Anders Gummesson and Margareta Jern{\aa}s and Niclas Franck and David D Kerrigan and Fredrik H Nystrom and Lena M. S. Carlsson and Harpal Randeva and Jonathan Pinkney and John P H Wilding},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Matricellular Secreted Protein, Acidic and Rich in Cysteine (SPARC), originally discovered in bone as osteonectin, is a mediator of collagen deposition and promotes fibrosis. Adipose tissue collagen has recently been found to be linked with metabolic dysregulation. Therefore, we tested the hypothesis that SPARC in human adipose tissue is influenced by glucose metabolism and adipokines. RESEARCH DESIGN AND METHODS Serum and adipose tissue biopsies were obtained from morbidly obese… CONTINUE READING

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