Regulation of the Expression of GARP/Latent TGF-β1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation

  title={Regulation of the Expression of GARP/Latent TGF-$\beta$1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation},
  author={J. Edwards and H. Fujii and Angela X. Zhou and J. Creemers and D. Unutmaz and E. Shevach},
  journal={The Journal of Immunology},
  pages={5506 - 5515}
GARP/LRRC32 was defined as a marker of activated human regulatory T cells (Tregs) that is responsible for surface localization of latent TGF-β1. We find that GARP and latent TGF-β1 are also found on mouse Tregs activated via TCR stimulation; however, in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL-2 or IL-4 exposure in the absence of TCR signaling. GARP is expressed at a low level on Tregs within… Expand
Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8
B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.
Role of GARP in the activation of latent TGF-β1.
Garp as a therapeutic target for modulation of T regulatory cell function
  • E. Shevach
  • Biology, Medicine
  • Expert opinion on therapeutic targets
  • 2017


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GARP: a key receptor controlling FOXP3 in human regulatory T cells
Membrane protein GARP is a receptor for latent TGF‐β on the surface of activated human Treg
Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
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CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β–dependent manner
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Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.