Regulation of the Escherichia coli cad operon: location of a site required for acid induction.

@article{Meng1992RegulationOT,
  title={Regulation of the Escherichia coli cad operon: location of a site required for acid induction.},
  author={Shirley Y. Meng and George N. Bennett},
  journal={Journal of bacteriology},
  year={1992},
  volume={174 8},
  pages={2670-8}
}
The cad operon encodes lysine decarboxylase and a protein homologous to amino acid antiporters. These two genes are induced under conditions of low pH, anaerobiosis, and excess lysine. The upstream regulatory region of the cad operon has been cloned into lacZ expression vectors for analysis of the sequences involved in these responses. Deletion analysis of the upstream region and cloning of various fragments to make cadA::lacZ or cadB::lacZ protein fusions or operon fusions showed that cadA was… CONTINUE READING

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