Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation

@inproceedings{Kaya2017RegulationOT,
  title={Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation},
  author={Kamber Kaya and Elie Hatem},
  year={2017}
}
Apoptosis is a programmed cell death mechanism that is evolutionary conserved from worms to humans. Apoptosis is mediated by initiator and effector caspases. The initiator caspases carry long pro-domains for their interaction with scaffolding proteins to form a cell-death platform, which is essential for their activation. Activated initiator caspases then cleave effector caspases that execute cell death through cleaving downstream targets. In addition to their apoptotic function, caspases also… CONTINUE READING

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