Regulation of the Drosophila Enhancer of split and invected-engrailed Gene Complexes by Sister Chromatid Cohesion Proteins

@inproceedings{Schaaf2009RegulationOT,
  title={Regulation of the Drosophila Enhancer of split and invected-engrailed Gene Complexes by Sister Chromatid Cohesion Proteins},
  author={Cheri A. Schaaf and Ziva Misulovin and Gurmukh Sahota and Akbar M. Siddiqui and Yuri B. Schwartz and Tatyana G. Kahn and Vincenzo Pirrotta and Maria Gause and Dale Dorsett},
  booktitle={PloS one},
  year={2009}
}
The cohesin protein complex was first recognized for holding sister chromatids together and ensuring proper chromosome segregation. Cohesin also regulates gene expression, but the mechanisms are unknown. Cohesin associates preferentially with active genes, and is generally absent from regions in which histone H3 is methylated by the Enhancer of zeste [E(z)] Polycomb group silencing protein. Here we show that transcription is hypersensitive to cohesin levels in two exceptional cases where… CONTINUE READING

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