Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growth.

@article{Bassilana2005RegulationOT,
  title={Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growth.},
  author={Martine Bassilana and Julie Hopkins and Robert A Arkowitz},
  journal={Eukaryotic cell},
  year={2005},
  volume={4 3},
  pages={588-603}
}
The Rho G protein Cdc42 and its exchange factor Cdc24 are required for hyphal growth of the human fungal pathogen Candida albicans. Previously, we reported that strains ectopically expressing Cdc24 or Cdc42 are unable to form hyphae in response to serum. Here we investigated the role of these two proteins in hyphal growth, using quantitative real-time PCR to measure induction of hypha-specific genes together with time lapse microscopy. Expression of the hypha-specific genes examined depends on… CONTINUE READING
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