Regulation of the CFTR channel by phosphorylation

@article{Dahan2001RegulationOT,
  title={Regulation of the CFTR channel by phosphorylation},
  author={D. Dahan and A. Evagelidis and J. Hanrahan and D. Hinkson and Y. Jia and J. Luo and T. Zhu},
  journal={Pfl{\"u}gers Archiv},
  year={2001},
  volume={443},
  pages={S92-S96}
}
  • D. Dahan, A. Evagelidis, +4 authors T. Zhu
  • Published 2001
  • Chemistry, Medicine
  • Pflügers Archiv
    • Abstract. Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels are regulated tightly by protein kinases and phosphatases. The regulatory domain of CFTR has about 20 potential sites for phosphorylation by protein kinases A (PKA) and C (PKC). The reason for this large number of sites is not known, however their conservation from fish to humans implies that they play important roles in vivo. PKA is an important activator, and its stimulation of CFTR is enhanced by PKC via… CONTINUE READING
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    References

    SHOWING 1-10 OF 45 REFERENCES
    Phosphatase inhibitors activate normal and defective CFTR chloride channels.
    • F. Becq, T. Jensen, +6 authors J. Hanrahan
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1994
    • 149
    Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites.
    • 288
    Phosphorylation by Protein Kinase C Is Required For Acute Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Protein Kinase A*
    • 209
    • PDF
    Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.
    • 421
    • PDF
    Phosphorylation of the cystic fibrosis transmembrane conductance regulator.
    • 276
    Stimulation of CFTR activity by its phosphorylated R domain
    • 142
    Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis.
    • 261
    • PDF
    Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator.
    • 107
    Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms
    • 218
    Association of Cystic Fibrosis Transmembrane Conductance Regulator and Protein Phosphatase 2C*
    • 65
    • PDF