Regulation of the CFTR channel by phosphorylation

  title={Regulation of the CFTR channel by phosphorylation},
  author={D. Dahan and A. Evagelidis and J. Hanrahan and D. Hinkson and Y. Jia and J. Luo and T. Zhu},
  journal={Pfl{\"u}gers Archiv},
  • D. Dahan, A. Evagelidis, +4 authors T. Zhu
  • Published 2001
  • Chemistry, Medicine
  • Pflügers Archiv
  • Abstract. Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels are regulated tightly by protein kinases and phosphatases. The regulatory domain of CFTR has about 20 potential sites for phosphorylation by protein kinases A (PKA) and C (PKC). The reason for this large number of sites is not known, however their conservation from fish to humans implies that they play important roles in vivo. PKA is an important activator, and its stimulation of CFTR is enhanced by PKC via… CONTINUE READING
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