Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.

@article{Graeser2002RegulationOT,
  title={Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.},
  author={Ralph Graeser and Julian Gannon and Randy Yat Choi Poon and Thierry Dubois and Alastair G. Aitken and Trevor C. Hunt},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 17},
  pages={
          3479-90
        }
}
PCTAIRE-1 is a CDK-related protein kinase found in terminally differentiated cells in brain and testis, and in many immortalised and transformed cell lines. Bacterially expressed PCTAIRE is completely inactive as a protein kinase, but is a very good substrate for protein kinase A (PKA), which phosphorylates a total of four sites in the N-terminus of PCTAIRE-1. Phosphorylation of one of these sites, Ser119, generates a 14-3-3 binding site, which is functional in vitro as well as in vivo… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Mutagenesis by the polymerase chain reaction

  • F. M. Ausubel, R. Brent, +4 authors K. Struhl
  • Current Protocols in Molecular Biology
  • 1999
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…