Corpus ID: 5818762

Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.

@article{Graeser2002RegulationOT,
  title={Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.},
  author={R. Graeser and J. Gannon and R. Poon and T. Dubois and A. Aitken and T. Hunt},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 17},
  pages={
          3479-90
        }
}
PCTAIRE-1 is a CDK-related protein kinase found in terminally differentiated cells in brain and testis, and in many immortalised and transformed cell lines. Bacterially expressed PCTAIRE is completely inactive as a protein kinase, but is a very good substrate for protein kinase A (PKA), which phosphorylates a total of four sites in the N-terminus of PCTAIRE-1. Phosphorylation of one of these sites, Ser119, generates a 14-3-3 binding site, which is functional in vitro as well as in vivo… Expand
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References

SHOWING 1-10 OF 41 REFERENCES
The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins
The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation.
  • V. Besset, K. Rhee, D. Wolgemuth
  • Biology, Medicine
  • Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
  • 1999
A brain-specific activator of cyclin-dependent kinase 5
PCTAIRE-1: characterization, subcellular distribution, and cell cycle-dependent kinase activity.
Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins.
...
1
2
3
4
5
...