Regulation of the Bub2/Bfa1 GAP Complex by Cdc5 and Cell Cycle Checkpoints

@article{Hu2001RegulationOT,
  title={Regulation of the Bub2/Bfa1 GAP Complex by Cdc5 and Cell Cycle Checkpoints},
  author={Fenghua Hu and Yanchang Wang and Dou Liu and Yumei Li and Jun Qin and Stephen J Elledge},
  journal={Cell},
  year={2001},
  volume={107},
  pages={655-665}
}
During mitosis, a ras-related GTPase (Tem1) binds GTP and activates a signal transduction pathway to allow mitotic exit. During most of the cell cycle, Tem1 function is antagonized by a GTPase-activating protein complex, Bfa1/Bub2. How the Bfa1/Bub2 complex is regulated is not well understood. We find that Polo/Cdc5 kinase acts upstream of Bfa1/Bub2 in the mitotic exit network. Cdc5 phosphorylates Bfa1 and acts to antagonize Bfa1 function to promote mitotic exit. Bfa1 is regulated by multiple… CONTINUE READING
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