Regulation of the Ah gene battery via Ah receptor-dependent and independent processes in cultured adult rat hepatocytes.

@article{Xiao1995RegulationOT,
  title={Regulation of the Ah gene battery via Ah receptor-dependent and independent processes in cultured adult rat hepatocytes.},
  author={G h Xiao and Jane A. Pinaire and A. David Rodrigues and Russell A. Prough},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1995},
  volume={23 6},
  pages={642-50}
}
A number of genes under the control of the arylhydrocarbon (Ah) receptor were tested for the effects of glucocorticoids on their expression in cultured primary rat hepatocytes. Treatment of cultured hepatocytes with 1.0 microM dexamethasone potentiated the induction (2- to 3-fold) of cytochrome P4501A1, glutathione S-transferase Ya subunit (GSTYa), and UDP-glucuronosyltransferase gene expression by polycyclic aromatic hydrocarbons (PAH), whereas the glucocorticoid agonist suppressed PAH… CONTINUE READING
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