Regulation of ternary (Met-tRNAf - GTP - eukaryotic initiation factor 2) protein synthesis initiation complex formation by the adenylate energy charge.

@article{Walton1976RegulationOT,
  title={Regulation of ternary (Met-tRNAf - GTP - eukaryotic initiation factor 2) protein synthesis initiation complex formation by the adenylate energy charge.},
  author={Grant Walton and Gordon N. Gill},
  journal={Biochimica et biophysica acta},
  year={1976},
  volume={418 2},
  pages={195-203}
}
Formation of the ternary [Met-tRNAf - GTP - eukaryotic initiation factor 2] protein synthesis initiation complex in rabbit reticulocyte ribosomal eluates is dependent on the GTP: GDP ratio and on the adenylate energy charge. The elements controlling ternary initiation complex formation have been studied in a reconstituted system contianing eukaryotic initiation factor 2 and nucleoside diphosphate kinase purified from the ribosomal eluate. The concentration of GTP required for half maximal… CONTINUE READING