Regulation of tension-induced mechanotranscriptional signals by the microtubule network in fibroblasts.

@article{DAddario2003RegulationOT,
  title={Regulation of tension-induced mechanotranscriptional signals by the microtubule network in fibroblasts.},
  author={Mario D'Addario and Pamela D Arora and Richard P. Ellen and C A McCulloch},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 52},
  pages={53090-7}
}
Mechanical loading of connective tissues induces the expression of extracellular matrix and cytoskeletal genes that are involved in matrix remodeling. These processes depend in part on force transmission through beta1 integrins and actin filaments, but the role of microtubules in regulating mechanotranscriptional responses is not well defined. We assessed the involvement of microtubules in the mechanotranscriptional regulation of filamin A, an actin-cross-linking protein that protects cells… CONTINUE READING