Regulation of temporal identity transitions in Drosophila neuroblasts.

  title={Regulation of temporal identity transitions in Drosophila neuroblasts.},
  author={Ruth Grosskortenhaus and Bret J Pearson and Amanda Marusich and Chris Q Doe},
  journal={Developmental cell},
  volume={8 2},
Temporal patterning is an important aspect of embryonic development, but the underlying molecular mechanisms are not well understood. Drosophila neuroblasts are an excellent model for studying temporal identity: they sequentially express four genes (hunchback --> Kruppel --> pdm1 --> castor) whose temporal regulation is essential for generating neuronal diversity. Here we show that hunchback --> Kruppel timing is regulated transcriptionally and requires neuroblast cytokinesis, consistent with… CONTINUE READING


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