Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation.

@article{Kim2008RegulationOT,
  title={Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation.},
  author={Mi Kyung Kim and Mi Ran Kang and Hyung Wook Nam and Y W Bae and Yu Sam Kim and I. K. Chung},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 20},
  pages={14144-52}
}
Telomere maintenance is essential for continued cell proliferation and chromosome stability. Telomeres are maintained by telomerase and a collection of associated proteins. The telomeric protein telomeric repeat binding factor 1 (TRF1) negatively regulates telomere length by inhibiting access of telomerase at telomere termini. Here we report that TRF1 interacts with the beta subunit of casein kinase 2 (CK2) and serves as a substrate for CK2. CK2-mediated phosphorylation is required for the… CONTINUE READING