Regulation of telomerase by telomeric proteins.

  title={Regulation of telomerase by telomeric proteins.},
  author={Agata Smogorzewska and Titia de Lange},
  journal={Annual review of biochemistry},
Telomeres are essential for genome stability in all eukaryotes. Changes in telomere functions and the associated chromosomal abnormalities have been implicated in human aging and cancer. Telomeres are composed of repetitive sequences that can be maintained by telomerase, a complex containing a reverse transcriptase (hTERT in humans and Est2 in budding yeast), a template RNA (hTERC in humans and Tlc1 in yeast), and accessory factors (the Est1 proteins and dyskerin in humans and Est1, Est3, and… CONTINUE READING

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