Regulation of synaptophysin degradation by mammalian homologues of seven in absentia.

@article{Wheeler2002RegulationOS,
  title={Regulation of synaptophysin degradation by mammalian homologues of seven in absentia.},
  author={Tiffany C Wheeler and Lih-Shen Chin and Yankun Li and Francine L Roudabush and Lian Li},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 12},
  pages={10273-82}
}
Synaptophysin is an integral membrane protein of synaptic vesicles characterized by four transmembrane domains with both termini facing the cytoplasm. Although synaptophysin has been implicated in neurotransmitter release, and decreased synaptophysin levels have been associated with several neurodegenerative diseases, the molecular mechanism that regulates the degradation of synaptophysin remains unsolved. Using the cytoplasmic C terminus of synaptophysin as bait in a yeast two-hybrid screen… CONTINUE READING
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