Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.

@article{Lee2004RegulationOS,
  title={Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.},
  author={Sang Yoon Lee and Markus R. Wenk and Yong Kim and Angus C. Nairn and Pietro De Camilli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 2},
  pages={546-51}
}
Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presynaptic nerve terminals, where it dephosphorylates a pool of phosphatidylinositol 4,5-bisphosphate implicated in synaptic vesicle recycling. Like other proteins with a role in endocytosis, synaptojanin 1 undergoes constitutive phosphorylation in resting synapses and stimulation-dependent dephosphorylation by calcineurin. Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates synaptojanin 1 and regulates its… CONTINUE READING