Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus.

  title={Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus.},
  author={Takeshi Kanno and Tomoyuki Nishizaki and Richard L Proia and Taketoshi Kajimoto and Saleem Jahangeer and Tomoya Okada and Shiro Nakamura},
  volume={171 4},
Although the hippocampus is a brain region involved in short-term memory, the molecular mechanisms underlying memory formation are not completely understood. Here we show that sphingosine 1-phosphate (S1P) plays a pivotal role in the formation of memory. Addition of S1P to rat hippocampal slices increased the rate of AMPA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) recorded from the CA3 region of the hippocampus. In addition long-term potentiation (LTP) observed in the… CONTINUE READING


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