Regulation of synaptic strength and AMPA receptor subunit composition by PICK1.

  title={Regulation of synaptic strength and AMPA receptor subunit composition by PICK1.},
  author={Akira Terashima and Lucy Cotton and Kumlesh K Dev and Guido Meyer and Shahid H Zaman and Fabrice Duprat and Jeremy M Henley and Graham L Collingridge and John T.R Isaac},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 23},
PICK1 (protein interacting with C kinase-1) regulates the surface expression of the AMPA receptor (AMPAR) GluR2 subunit, however, the functional consequences of this interaction are not well understood. Previous work has suggested that PICK1 promotes the internalization of AMPARs. However, we found that when PICK1 is virally expressed in the CA1 region of hippocampal slices, it causes an increase in AMPAR-mediated EPSC amplitude. This effect is associated with increased AMPAR rectification and… CONTINUE READING
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