Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels.

@article{Bloodgood2008RegulationOS,
  title={Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels.},
  author={Brenda L Bloodgood and Bernardo L. Sabatini},
  journal={The Journal of physiology},
  year={2008},
  volume={586 6},
  pages={1475-80}
}
Activation of glutamatergic synapses onto pyramidal neurons produces a synaptic depolarization as well as a buildup of intracellular calcium (Ca(2+)). The synaptic depolarization propagates through the dendritic arbor and can be detected at the soma with a recording electrode. Current influx through AMPA-type glutamate receptors (AMPARs) provides the depolarizing drive, and the amplitudes of synaptic potentials are generally thought to reflect the number and properties of these receptors at… CONTINUE READING