Regulation of sympathetic presynaptic components in rat left ventricle during ligation of abdominal aorta.

@article{NyquistBattie1996RegulationOS,
  title={Regulation of sympathetic presynaptic components in rat left ventricle during ligation of abdominal aorta.},
  author={Cynthia Nyquist-Battie and Pamela K. Cochran and Vincent Evans and J M Hitchcock and Ciğdem Unal},
  journal={The American journal of physiology},
  year={1996},
  volume={271 4 Pt 2},
  pages={H1547-54}
}
To assess the effects of long-term pressure overload on sympathetic presynaptic components in the left ventricle, young adult male rats were subjected to surgical constriction of the suprarenal abdominal aorta. At 4 and 8 wk postsurgery, but not at 1 wk, left ventricular sympathetic activity, measured by the net fractional norepinephrine (NE) decrease after alpha-methyl-p-tyrosine methyl ester administration, was elevated in the aortic-banded rats. However, left ventricular NE was reduced only… CONTINUE READING