Regulation of surfactant protein D in human fetal lung.

@article{Dulkerian1996RegulationOS,
  title={Regulation of surfactant protein D in human fetal lung.},
  author={S J Dulkerian and Linda W. Gonzales and Yaoyu Ning and Philip L. Ballard},
  journal={American journal of respiratory cell and molecular biology},
  year={1996},
  volume={15 6},
  pages={
          781-6
        }
}
Surfactant protein D (SP-D) is a collagenous glycoprotein, produced by lung type II cells, that has structural and functional similarities with SP-A. In this study we postulated that SP-D and SP-A gene expression are regulated in a similar fashion to provide a coordinated local immune defense response to pulmonary infection. We determined content of SP-D protein and mRNA in second-trimester fetal lung and in postnatal tissue by protein blotting and hybridization analyses. Low levels of SP-D… CONTINUE READING

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