Regulation of substrate adhesion dynamics during cell motility.

  title={Regulation of substrate adhesion dynamics during cell motility.},
  author={Irina Kaverina and Olga Krylyshkina and John Victor Small},
  journal={The international journal of biochemistry & cell biology},
  volume={34 7},
The movement of a metazoan cell entails the regulated creation and turnover of adhesions with the surface on which it moves. Adhesion sites form as a result of signaling between the extracellular matrix on the outside and the actin cytoskeleton on the inside, and they are associated with specific assembles of actin filaments. Two broad categories of adhesion sites can be distinguished: (1) "focal complexes" associated with lamellipodia and filopodia that support protrusion and traction at the… CONTINUE READING