Regulation of store-operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubes.

@article{Vandebrouck2006RegulationOS,
  title={Regulation of store-operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubes.},
  author={Aur{\'e}lie Vandebrouck and Thomas Ducret and Olivier Basset and S. Sebille and G. Raymond and Urs T. Ruegg and Philippe Gailly and C. Cognard and B. Constantin},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 1},
  pages={136-8}
}
Defective expression of dystrophin in muscle cells is the primary feature of Duchenne muscular dystrophy (DMD), which is accompanied by fiber necrosis and intracellular calcium mishandling. These features led to the hypothesis that dystrophin could control calcium movements. Calcium mishandling in human DMD myotubes is dependent on contraction and/or calcium release activity, suggesting the involvement of channels being activated during these processes. Forced expression of minidystrophin at… CONTINUE READING

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