Regulation of sterol synthesis in eukaryotes.

@article{Espenshade2007RegulationOS,
  title={Regulation of sterol synthesis in eukaryotes.},
  author={P. Espenshade and A. Hughes},
  journal={Annual review of genetics},
  year={2007},
  volume={41},
  pages={
          401-27
        }
}
  • P. Espenshade, A. Hughes
  • Published 2007
  • Biology, Medicine
  • Annual review of genetics
  • Cholesterol is an essential component of mammalian cell membranes and is required for proper membrane permeability, fluidity, organelle identity, and protein function. Cells maintain sterol homeostasis by multiple feedback controls that act through transcriptional and posttranscriptional mechanisms. The membrane-bound transcription factor sterol regulatory element binding protein (SREBP) is the principal regulator of both sterol synthesis and uptake. In mammalian cells, the ER membrane protein… CONTINUE READING
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