Regulation of sterol synthesis in eukaryotes.

  title={Regulation of sterol synthesis in eukaryotes.},
  author={P. Espenshade and A. Hughes},
  journal={Annual review of genetics},
  • P. Espenshade, A. Hughes
  • Published 2007
  • Biology, Medicine
  • Annual review of genetics
  • Cholesterol is an essential component of mammalian cell membranes and is required for proper membrane permeability, fluidity, organelle identity, and protein function. Cells maintain sterol homeostasis by multiple feedback controls that act through transcriptional and posttranscriptional mechanisms. The membrane-bound transcription factor sterol regulatory element binding protein (SREBP) is the principal regulator of both sterol synthesis and uptake. In mammalian cells, the ER membrane protein… CONTINUE READING
    452 Citations
    Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
    • 8
    • PDF
    Dual functions of Insig proteins in cholesterol homeostasis
    • 42
    Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
    • 119
    • PDF
    Regulation of HMG-CoA reductase in mammals and yeast.
    • 184
    SREBPs: the crossroads of physiological and pathological lipid homeostasis
    • 262
    The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis
    • 29
    • PDF


    Proteolysis and sterol regulation.
    • R. Hampton
    • Biology, Medicine
    • Annual review of cell and developmental biology
    • 2002
    • 99
    • PDF
    SREBP in signal transduction: cholesterol metabolism and beyond.
    • 246
    Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins.
    • 68
    • PDF
    Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.
    • 234
    • PDF
    The SREBP pathway in Drosophila: regulation by palmitate, not sterols.
    • 156
    • PDF
    Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiae.
    • 57
    • Highly Influential
    • PDF
    SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
    • 3,773
    • PDF
    Membrane Topology of Human Insig-1, a Protein Regulator of Lipid Synthesis*
    • 82
    • PDF
    SREBP Pathway Responds to Sterols and Functions as an Oxygen Sensor in Fission Yeast
    • 272
    • PDF