Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family.

@article{Manna2002RegulationOS,
  title={Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family.},
  author={Pulak Ranjan Manna and Matthew T. Dyson and Darrell W Eubank and Barbara J. Clark and Enzo Lalli and Paolo Sassone-Corsi and Anthony J. Zeleznik and Douglas M. Stocco},
  journal={Molecular endocrinology},
  year={2002},
  volume={16 1},
  pages={184-99}
}
The mitochondrial phosphoprotein, the steroidogenic acute regulatory (StAR) protein, is an essential component in the regulation of steroid biosynthesis in adrenal and gonadal cells through cAMP-dependent pathways. In many cases transcriptional induction by cAMP is mediated through the interaction of a cAMP response-element binding protein (CREB) family member with a consensus cAMP response element (CRE; 5'-TGACGTCA-3') found in the promoter of target genes. The present investigation was… CONTINUE READING
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