Regulation of steroid glucuronosyltransferase activities and transcripts by androgen in the human prostatic cancer LNCaP cell line.

@article{Guillemette1996RegulationOS,
  title={Regulation of steroid glucuronosyltransferase activities and transcripts by androgen in the human prostatic cancer LNCaP cell line.},
  author={Chantal Guillemette and Dean W. Hum and Alain B{\'e}langer},
  journal={Endocrinology},
  year={1996},
  volume={137 7},
  pages={2872-9}
}
Although much attention has been focused on the synthesis of dihydrotestosterone (DHT), the inactivation and elimination of active androgens can also be key points in regulating androgen levels in tissues such as the prostate. Recent data suggest that 5alpha-reduced C19 steroids can be converted to glucuronide derivatives in the human prostate, leading to… CONTINUE READING