Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.

@article{Tallczy2002RegulationOS,
  title={Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.},
  author={Zsolt Tall{\'o}czy and Wenxia Jiang and Herbert W Virgin and David A. Leib and Donalyn L. Scheuner and Randal J Kaufman and E L Eskelinen and Beth Levine},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 1},
  pages={190-5}
}
The eIF2alpha kinases are a family of evolutionarily conserved serine/threonine kinases that regulate stress-induced translational arrest. Here, we demonstrate that the yeast eIF2alpha kinase, GCN2, the target phosphorylation site of Gcn2p, Ser-51 of eIF2alpha, and the eIF2alpha-regulated transcriptional transactivator, GCN4, are essential for another fundamental stress response, starvation-induced autophagy. The mammalian IFN-inducible eIF2alpha kinase, PKR, rescues starvation-induced… CONTINUE READING
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