Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting, and diabetes.

@article{Adamo1991RegulationOS,
  title={Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting, and diabetes.},
  author={Martin L. Adamo and Herzl Ben-Hur and Charles Roberts and Derek Leroith},
  journal={Molecular endocrinology},
  year={1991},
  volume={5 11},
  pages={1677-86}
}
Rat insulin-like growth factor-I (IGF-I) mRNAs with different 5'-untranslated region/prepeptide coding sequences result from transcription initiation in one of two leader exons. While not altering the mature IGF-I coding sequence, these different leaders potentially encode two distinct IGF-I prepeptides, one of 48 amino acids (exon 1) and one of 32 amino acids (exon 2). Within exon 1, transcription initiation is dispersed (i.e. occurs over a approximately 350-basepair region), while within exon… CONTINUE READING

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