Regulation of stability and synthesis of EGF-receptor mRNAs encoding for intact and truncated receptor forms.

@article{Kesavan1990RegulationOS,
  title={Regulation of stability and synthesis of EGF-receptor mRNAs encoding for intact and truncated receptor forms.},
  author={Prabakaran Kesavan and Paromita Das and Jeffrey P. Kern and Manjusri Das},
  journal={Oncogene},
  year={1990},
  volume={5 4},
  pages={483-8}
}
The EGF-receptor is a proto-oncogene encoded membrane protein related to the v-erb-B oncogene product of avian erythroblastosis virus. Here we have studied the expression and stability characteristics of two forms of receptor mRNA--a 5.6 kb form that encodes for the intact transmembrane 170 kDa receptor and a 3' deleted 2.6 kb form that encodes for a 100 kDa secreted EGF-receptor. In previous studies we showed that EGF increased the synthesis of its own receptor in human cytotrophoblasts and… CONTINUE READING

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